LOT YPB.255✓ COA VERIFIED
Compound information
Molecular profile
What is FOXO4?
Reference data for this compound is being added. Every lot still ships with its third-party Certificate of Analysis.
Storage requirements
Stability information
Protect from lightRoom-temp stable (short-term)
Lyophilized (powder)−20°C · stable long-term
Reconstituted2–8°C · use within 30 days
Lab verification
Verified by a third-party lab
This lotYPB.255
TestedDec 2025 · USA
Result6 of 6 tests passed
Research overview
FOXO4 in the literature
Contents FOXO4 D-Retro-Inverso Form / storage Lyophilized powder; store at −20 °C, protect from light Purity ≥98% — see lot COA CAS 2460055-10-9 Molecular formula C234H380N76O68S2 Molecular weight ~5382.1 g/mol Sizes 10 mg Testing Identity (UV/Vis λmax), purity, assay (Beer-Lambert), heavy metals, microbial (TAMC/TYMC) COA Batch-specific — view on this page Research background FOXO4-DRI is a D-retro-inverso analogue of a segment of the FOXO4 transcription factor, built entirely from D-amino acids in reversed sequence — preserving the geometry needed to engage its target while resisting proteolytic degradation. It is a widely cited tool compound in cellular-senescence research. Senescent cells are reported to depend on elevated FOXO4 to sequester p53 and evade apoptosis; FOXO4-DRI is investigated for competitively disrupting this interaction, releasing p53 and selectively driving senescent cells toward apoptosis in preclinical systems while reportedly sparing healthy dividing cells. Introduced in a landmark 2017 Cell study.
HighlightsSenescent cells are reported to depend on elevated FOXO4 to sequester p53 and evade apoptosis; FOXO4-DRI is investigated for competitively disrupting this interaction, releasing p53 and selectively driving senescent cells toward apoptosis in preclinical systems while reportedly sparing healthy dividing cells.Introduced in a landmark 2017 Cell study.Research applications Selective senolytic tool in cellular-senescence research Preclinical aging and tissue-homeostasis models Probe of the FOXO4–p53 protein-protein interaction in vitro Quality & documentation Every lot is tested by an independent third-party laboratory before it enters the catalog.Testing covers identity (characteristic UV/Vis λmax matched to a reference standard), percent purity (≥98%, correlation-coefficient method), quantitative assay (Beer-Lambert, ≥95% of label claim), heavy metals (total ≤150 ppb — Pb, Cd, Hg, Ni, Fe, Co), and microbial limits (TAMC/TYMC).
COA breakdown
✓ 6 of 6 tests passedPASSIdentityλ-max matchesLambda-max vs reference standardPASSPurity≥98% · UV/VisUV/Vis correlationPASSQuantitative assay≥95% of labelBeer-Lambert · ≥95% label claimPASSHeavy metals<20 ppbNMT 150 ppb/vial specPASSTAMC · aerobic microbial0 CFUNMT 1,000 CFU · 48 h @ 37 °CPASSTYMC · yeast & mold0 CFUNMT 100 CFU · 48 h @ 30 °C
Purity is measured per lot; panel results per the Analytical Formulations summary report for the lot currently shipping.
Product details
- Type
- Research peptide
- Form
- Lyophilized powder
- Storage
- Room temp in transit · −20 °C long-term
